Friday, January 31, 2014

Cannabis oil helping leukemia

Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation.

 

Case Rep Oncol. 2013 Nov 28;6(3):585-92. doi: 10.1159/000356446. eCollection 2013.

Abstract

Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells and is typically well treated with combination chemotherapy, with a remission state after 5 years of 94% in children and 30-40% in adults. To establish how aggressive the disease is, further chromosome testing is required to determine whether the cancer is myeloblastic and involves neutrophils, eosinophils or basophils, or lymphoblastic involving B or T lymphocytes. This case study is on a 14-year-old patient diagnosed with a very aggressive form of ALL (positive for the Philadelphia chromosome mutation). A standard bone marrow transplant, aggressive chemotherapy and radiation therapy were revoked, with treatment being deemed a failure after 34 months. Without any other solutions provided by conventional approaches aside from palliation, the family administered cannabinoid extracts orally to the patient. Cannabinoid resin extract is used as an effective treatment for ALL with a positive Philadelphia chromosome mutation and indications of dose-dependent disease control. The clinical observation in this study revealed a rapid dose-dependent correlation.

KEYWORDS:

Acute lymphoblastic leukemia, Cannabinoids, Hemp oil, Philadelphia chromosome

 

Monday, November 25, 2013

THC May Treat Inflammatory Diseases and Cancer By Altering Genes

http://www.jbc.org/content/early/2013/11/07/jbc.M113.503037.short#ref-list-1

An intriguing new government funded study published by the Journal of Biological Chemistry has found that THC may actually alter certain genes in our body, which may result in a positive effect on a number of conditions, especially cancers and inflammatory diseases.

Researchers using rat models found that THC positively altered 13 different microRNAs, including mir-690, which is strongly linked to inflammatory responses; the study claims that; “Among the differentially expressed, miRNA-690 was highly overexpressed in THC-MDSC (~16 fold)”.
According to researchers; “Select miRNA such as mir-690 targeting genes involved in myeloid expansion and differentiation likely play crucial roles in this process and therefore in cannabinoid-induced immunosuppression.”
They conclude that these results indicate that THC may treat “inflammatory diseases as well as cancer.”
The study was funded by the U.S. National Institute of Health.

Monday, October 28, 2013

Cannabis may help reverse dementia: study


Cannabis may help reverse dementia: study

Cannabis may help reverse dementia: study

Date
February 6, 2013

Amy Corderoy
Amy Corderoy
Health Editor, Sydney Morning Herald

View more articles from Amy Corderoy

It makes most people a little foggy-headed, but scientists are investigating whether an active ingredient in cannabis could actually stave off dementia.

A team from Neuroscience Research Australia is in the early stages of research examining if one of the main active ingredients in cannabis, called cannabidiol, could reverse some of the symptoms of memory loss in animals.

Tim Karl, a senior research fellow with the group, said cannabidiol does not have the same psychoactive effects as the main component of marijuana, THC, but it has been found to have anti-inflammatory, antioxidant and other effects that could be beneficial for the brain.

“Back in the day cannabis was used for medical purposes, I'm talking 200 years, 100 years back, then at some point people discovered it had other effects and, as quite often happens in our society, people decided it was a bad drug,” he said.
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“But it's not one compound, it is a mixture of 60 different compounds, and you just have to look at those different compounds because some of them might be good for you.”

His study involved injecting cannabidiol into mice that had been bred to have similar symptoms as those seen in Alzheimer's, as well as examining what would happen to brain cells treated with the drug.

Dr Karl found that when the mice were given the cannabidiol they showed drastic improvement on parts of the tests that were related to recognising and remembering objects and other mice.

“It basically brings the performance of the animals back to the level of healthy animals,” he said. “You could say it cured them, but we will have to go back and look at their brains to be sure.”

The study was done as part of the PhD of student David Cheng, who has also collected the brains of the mice and intends to examine them to see if they showed physical improvements.

As part of the research, which is being presented at the Australian Neuroscience Society annual meeting in Melbourne this week, the team also treated animal brain cells that produced a protein linked to the development of plaques in the brain in humans with Alzheimer's disease, amyloid precursor protein.

The cell research, done at the University of Wollongong, found treating the cells with cannabidiol also reduced the amount of the harmful protein that they produced.

Dr Karl said there had been case reports in medical literature of marijuana smokers who had developed Alzheimer's disease, only to find their smoking seemed to relieve some of their symptoms.

“Most of the components [of marijuana] are detrimental, they worsen your cognitive performance and have psychoactive effects… cannabidiol seems to not have any of these negative effects,” he said.

http://www.smh.com.au/national/cannabis-may-help-reverse-dementia-study-20130206-2dxsk.html#ixzz2j49Wiotc

Cannabinoids Destroy Leukemia Cells, New Study Finds

New research has shown that the non-hallucinogenic components of cannabis could act as effective anti-cancer agents.
The anti-cancer properties of tetrahydrocannabinol (THC), the primary hallucinogenic component of cannabis, has been recognised for many years, but research into similar cannabis-derived compounds, known as cannabinoids, has been limited.
The study was carried out by a team at St George’s, University of London. It has been published in the journal Anticancer Research.
The team, led by Dr Wai Liu and colleagues carried out laboratory investigations using a number of cannabinoids, either alone or in combination with each other, to measure their anti-cancer actions in relation to leukaemia.
Of six cannabinoids studied, each demonstrated anti-cancer properties as effective as those seen in THC. Importantly, they had an increased effect on cancer cells when combined with each other.
Dr Liu said: “This study is a critical step in unpicking the mysteries of cannabis as a source of medicine. The cannabinoids examined have minimal, if any, hallucinogenic side effects, and their properties as anti-cancer agents are promising.
“These agents are able to interfere with the development of cancerous cells, stopping them in their tracks and preventing them from growing. In some cases, by using specific dosage patterns, they can destroy cancer cells on their own.
“Used in combination with existing treatment, we could discover some highly effective strategies for tackling cancer. Significantly, these compounds are inexpensive to produce and making better use of their unique properties could result in much more cost effective anti-cancer drugs in future.”
This latest research is part of a growing portfolio of studies into the medicinal properties of cannabis by the research team at St George’s. The next step will be to examine in the laboratory these compounds in combination with existing anti-cancer treatments and study treatment schedules to identify strategies that will maximise their efficacy.
The study examined two forms of cannabidiol (CBD), two forms of cannabigerol (CBG) and two forms of cannabigevarin (CBGV). These represent the most common cannabinoids found in the cannabis plant apart from THC.
http://ar.iiarjournals.org/content/33/10/4373.abstract

Tuesday, October 15, 2013

THC Cannabinoid Helpful in Treatment of Parkinson’s

Posted by Monterey Bud & filed under marijuana research, marijuana studies.
Weed - New Research: THC Cannabinoid Helpful in Treatment of Parkinson’s

Add this November 2013 report – soon to be published in the Journal of Neurology, Neurosurgery & Psychiatry  (in next month’s hard copy issue) – to the long list of scientific research, documenting marijuana’s THC cannabinoid as  demonstrating remarkable positive medicinal effects. Already accessible to the public,  the National Institute of Health was the first to disseminate the report online:


“Δ9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPARγ DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON’S DISEASE.”

Abstract

INTRODUCTION:

Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) are neuroprotective in animal and cell culture models of Parkinson’s disease (PD). In a PD cell culture model we recently demonstrated that Δ9-THC is neuroprotective through activation of the nuclear receptor peroxisomal proliferator-activated receptor γ (PPARγ). Furthermore, activation by specific agonists rosiglitazone and pioglitazone, has also been found neuroprotective. PPARγ is a nuclear receptor whose activation can lead to the expression of proteins involved in the de novo synthesis of mitochondria. One such protein is the PPARγ co-activator 1 α (PGC1α) as it co-activates NRF-1 mediated gene expression which is essential for the production of nuclear encoded, mitochondrial proteins. Here we investigate the effect of Δ9-THC and pioglitazone on mitochondrial biogenesis.

METHODS:

SH-SY5Y neuroblastoma cells were differentiated with retinoic acid and exposed to the PD relevant mitochondrial complex 1 inhibitor, MPP+. Δ9-THC and pioglitazone were co-administered with the minimum concentration of the specific PPARγ antagonist T0070907 able to block the protective effect of each compound respectively for 48 hours. The production of reactive oxygen species was then measured, proteins were extracted for Western blotting and total DNA was extracted to determine mitochondrial DNA (mtDNA) content by QPCR.

RESULTS:

Δ9-THC resulted in significant inhibition of MPP+ induced oxidative stress which was completely reversed by T0070907 whereas pioglitazone induced reduction in oxidative stress did not seem to be PPARγ dependent. Accordingly, both pioglitazone and Δ9-THC were able to restore MPP+ induced down-regulation of PGC1α, to the level of untreated control. This effect was inhibited by T0070907 in the case of Δ9-THC but not pioglitazone. Whilst NRF1 expression remained unaffected by all treatments, the mitochondrial transcription factor (tfam) which is necessary for mtDNA replication was reduced with MPP+ and up-regulated by Δ9-THC only. Similarly, mtDNA content and the mitochondrial marker COX4 were only increased by Δ9-THC.

CONCLUSIONS:

Even though Δ9-THC and pioglitazone are both protective against MPP+ only Δ9-THC induces PPARγ dependent mitochondrial biogenesis, a mechanism that may be beneficial for the treatment of PD.

Monday, July 29, 2013

34 Medical Studies Proving Cannabis Cures Cancer

http://www.wakingtimes.com/2013/07/27/34-medical-studies-proving-cannabis-cures-cancer/


WIKI - Cannabis5
Michael Taillard, Guest
Waking Times
There’s still a lot of confusion across the nation about whether or not marijuana is effective for cancer patients. Odds are you’ve heard something about it but weren’t sure whether the information was reliable or definitive. So, in order to help clear things up, here is a list of 34 studies showing that marijuana cures cancer, categorized by the type of cancers being cured in each study. As you sort through the articles, note that the consistent theme between them is that cannabis shrinks tumors and selectively targets cancer cells. As bills and voter initiatives to legalize medical marijuana spread from state to state, remember that we’re not just talking about mitigating the side effects of chemo (though this is another viable use), we’re talking about curing the cancer itself as well as preventing its spread. I’ve taken the liberty of only including articles from credible scientific journals, removing any biased or otherwise improperly cited studies. Enjoy!

Cures Brain Cancer

http://www.nature.com/bjc/journal/v95/n2/abs/6603236a.html
http://www.ncbi.nlm.nih.gov/pubmed/11479216
http://www.jneurosci.org/content/21/17/6475.abstract
http://jpet.aspetjournals.org/content/308/3/838.abstract
http://mct.aacrjournals.org/content/10/1/90.abstract

Cures Mouth and Throat Cancer

http://www.ncbi.nlm.nih.gov/pubmed/20516734

Cures Breast Cancer

http://www.ncbi.nlm.nih.gov/pubmed/20859676
http://www.ncbi.nlm.nih.gov/pubmed/18025276
http://www.ncbi.nlm.nih.gov/pubmed/21915267
http://jpet.aspetjournals.org/content/early/2006/05/25/jpet.106.105247.full.pdf+html
http://www.molecular-cancer.com/content/9/1/196
http://www.ncbi.nlm.nih.gov/pubmed/22776349
http://www.pnas.org/content/95/14/8375.full.pdf+html

Cures Lung Cancer

http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract
http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract
http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html

Cures Uterine, Testicular, and Pancreatic Cancers

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4
http://cancerres.aacrjournals.org/content/66/13/6748.abstract

Cures Prostate Cancer

http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/22594963

Cures Colorectal Cancer

http://www.ncbi.nlm.nih.gov/pubmed/22231745

Cures Ovarian Cancer

http://www.aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1084

Curse Blood Cancer

http://www.ncbi.nlm.nih.gov/pubmed/12091357
http://www.ncbi.nlm.nih.gov/pubmed/16908594
http://onlinelibrary.wiley.com/doi/10.1002/ijc.23584/abstract
http://molpharm.aspetjournals.org/content/70/5/1612.abstract

Cures Skin Cancer

http://www.ncbi.nlm.nih.gov/pubmed/12511587

Cures Liver Cancer

http://www.ncbi.nlm.nih.gov/pubmed/21475304

Cures Biliary Tract Cancer

http://www.ncbi.nlm.nih.gov/pubmed/19916793

Cures Bladder Cancer

http://www.medscape.com/viewarticle/803983 (Sign-up required to view study)

Cures Cancer in General

http://www.ncbi.nlm.nih.gov/pubmed/12514108
http://www.ncbi.nlm.nih.gov/pubmed/15313899
http://www.ncbi.nlm.nih.gov/pubmed/15313899

Thursday, June 6, 2013

2013: An Excellent Year for Cannabis Research

http://thejointblog.com/2013-an-excellent-year-for-cannabis-research/


Only five full months into the year, and 2013 has already been one of the best in regards to meaningful and impactful cannabis-related studies and research. As time goes55555 by science continues to crush decades of absurd propaganda, in addition to finding benefits of cannabis and ending its prohibition that even advocates may not have expected. The more cannabis science that’s released, the easier it becomes to get the public to understand and pay attention to its vast benefits.
Here’s a list of some of the most important cannabis studies to come out this year. We look forward to the studies yet to be released.
  • Study Shows Cannabis May Reverse Symptoms of Dementia – February, 2013: A group from Neuroscience Research Australia has found early evidence that cannabidiol – one of the main ingredients in cannabis – may reverse some of the symptoms of dementia, specifically Alzheimer’s disease. “It basically brings the performance of the animals back to the level of healthy animals,” said Tim Karl, one of the study’s researchers.