Friday, September 23, 2016

U.S. Attorney General Admits Marijuana Is Not a Gateway Drug

https://www.merryjane.com/news/us-attorney-general-admits-marijuana-not-gateway-drug

Top federal official crushes this popular anti-legalization argument.

One of the most popular arguments against the legalization of marijuana is that pot is a “gateway” drug with the potential to turn the great American populous into a nation of dope fiends. But today the country’s leading law enforcement official denounced this common misconception by admitting that the consumption of marijuana does not lead to the use of harder drugs.
As part of what President Obama has declared National Prescription Opioid and Heroin Epidemic Awareness Week, U.S Attorney General Loretta Lynch appeared at town hall meeting this morning in Richmond, Kentucky to discuss the dangers of opioid abuse with a group of teens.
In her opening statement, Lynch was adamant that the leading culprit behind Kentucky’s heroin epidemic was the use of prescription drugs.
“When you look at someone that, for example, has a heroin problem, it very often started with a prescription drug problem. Something totally legal. Something in every medicine cabinet. Something you can have prescribed to you in good faith by a doctor,” Lynch said before taking questions from the audience.
It did not take long before the discussion turned to the issue of marijuana.
Tyler Crafton, a student at Madison Central High School, took the opportunity to ask Lynch whether she thought the recreational use of marijuana among high school kids would lead to opioid abuse.
Shockingly, Lynch, the top dog at the U.S. Department of Justice, did provide the young man with a response straight out of the federal government’s propaganda handbook.
“There a lot of discussion about marijuana these days. Some states are making it legal, people are looking into medical uses for it, and I understand that it still is as common as almost anything,” Lynch replied. “When we talk about heroin addiction, we unusually, as we have mentioned, are talking about individuals that started out with a prescription drug problem, and then because they need more and more, they turn to heroin. It isn’t so much that marijuana is the step right before using prescription drugs or opioids.”
For a moment, it sounded as though the Attorney General was preparing to backtrack on her statement to some degree, adding that, “if you tend to experiment with a lot of things if life you may be more inclined to experiment with drugs.”
But then Lynch followed up with what should be considered one of the most important statements a federal official has made in 2016.
“It’s not as though we are seeing that marijuana is a specific gateway,” she said.
The attorney general’s admission that marijuana is not a gateway drug is fairly consistent with the National Institute on Drug Abuse, which finds “the majority of people who use marijuana do not go on to use other, “harder” substances. Yet many of marijuana’s opposing forces are going up against ballot measure in several states this election season by trying to convince the general public that legal weed will cause the opioid epidemic to spin further out of control.
Interestingly, an investigational report published earlier this week by the Associated Press and the Center for Public Integrity found that lobbyists for the drug makers responsible for the same prescription drugs that Attorney General Lynch says is responsible for the opioid epidemic have spent $880 million legally bribing state representatives and senators to vote against legislation concerning the restricting of opioid use. It stands to reason that these lobbyists are also responsible for getting federal lawmakers to turn a blind eye to marijuana.
Attorney General Lynch will be speaking at more than 250 events this week in support of Prescription Opioid and Heroin Epidemic Awareness Week. It will be interesting to see if she offers additional comments about the safety of marijuana.

Tuesday, September 20, 2016

Where to find good quality RSO or Hemp Extracts?

I get this question quite a bit, if you aren't able to make the oil yourself, then here is a list of legit providers

California
California Tears
Synergy Wellness

Oregon
Genesis Pharms

Washington
Health Max Group  (CBD Only)

Worldwide
Hemp Oil Shop
Endoca (CBD Only)

Monday, September 5, 2016

Boy on His Deathbed is Cured with Cannabis

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In a last ditch effort to save his life, 17-year-old Alexander “AJ” Kephart’s dedicated parents, Sheila and Chris, decided to try out cannabis oil on their dying son with miraculous results. Here’s one American family’s painful, inspirational, devastating and heroic medical cannabis cures-cancer story.
AJ’s super supportive father, Chris, admits his son’s story is complicated–even doctors have a hard time understanding everything he is now “missing” and how he’s been put back together (with titanium, prosthetics and even a “cage” around his back after having three vertebrae removed).
It all started in August 2012 when AJ noticed a persistent pain in his knee. In January 2013, he was diagnosed as having bone cancer. Later it was found that he also had stage four lung carcinoma as well.
That’s when AJ started chemotherapy. In May of the same year, his entire knee was removed along with some bone in his thigh and calf. At this point, doctors also found six tumors on all four of his lung chambers. To keep his lungs from collapsing, AJ was kept in the hospital for months hooked up to a breathing apparatus.
AJ was healing up when the cancer returned in 2014. He had his first three vertebrae removed, his top two ribs and sections of his back removed. The surgery itself even had to be stopped halfway as AJ was losing the use of his nerves. He ended up having to wear a cage around his body until the surgery could be completed a week or so later.
Just a few months after the spine surgery, AJ’s oncologist, Dr. Susan Storch, informed Sheila and Chris that his left lung lobe was covered with 20 plus cancerous tumors. They started chemo. Again.
Aj
That’s when they got the news: It’s time to “get your son’s things in order,” said the doctors. They gave AJ only a month more to live.
In complete desperation, Sheila and Chris asked their doctor about medical cannabis and its cancer-fighting effects. Dr. Storch agreed cannabis oil would be a good “alternative” medicine to pursue along with another series of chemotherapy sessions. She recommended cannabis pioneer Dr. Bonni Goldstein.
In her Lawndale, California office, Dr. Goldstein explained how cannabinoids–especially CBD–work by telling cancer cells to commit suicide plus it stops the formation of new capillaries, which cancer cells need to grow and spread. But even Dr. Goldstein had to admit AJ’s case was going to be experimental as she has never before treated a child with this particular cancer.
On the way home to Simi Valley, the Kepharts made a stop in Beverly Hills to Tracy Ryan’s then new cannabis clinical built specifically for children, CannaKids. “When we met AJ, he was super frail and was wearing a neck brace. He was taking handfuls of pain medications daily. His Mother Sheila was terrified and she looked like her soul had been ripped out,” remembers Ryan, whose daughter Sophie was healed of a brain tumor via cannabis oil.
In fact, AJ was in excruciating pain. His father Chris says AJ was taking two of the following each day for pain: OxyContin, Norco, Tylenol and Motrin. Without the pain killers, AJ would scream and cry in horrendous pain whenever he was awake.
After five days on CBD and THC oils by CannaKids, Chris says AJ’s pain has decreased so much that he was down to taking only one OxyContin daily. “Wow,” he exclaimed when remembering this stress-relieving moment for the whole family.
Because AJ had nothing to lose, his loving parents decided to speed up the dosage process. Dr. Goldstein had recommended a three-month process to increase the dosage, but Chris decided to fly at warp speed.
In two weeks, AJ was up to the highest dosage, but he was also tired all the time and felt loopy. “No, son,” father Chris said to AJ, “you are just stoned out of your mind.” Chris admits that this was a sad, but comical moment for father and son.
Two months later, the Kepharts visited their oncologist who was shocked that AJ looked much better and stronger. She also discovered his white blood cell counts showed lots of improvement. Four months later, a scan showed the multiple tumors on AJ’s lungs were completely gone.
Chris says Dr. Storch told them something like: “I can’t explain it. There’s no reason for it. But your scan came back totally clear. There’s no cancer. There’s no tumors in his lungs. It’s all gone.”
Since then, every scan has shown there’s no longer any cancer. “I believe cannabis is keeping him alive,” says Chris.
Very unfortunately, high dosage medical grade cannabis oil is expensive and costs the Kepharts almost $2,000 a month to keep AJ cancer and pain free. The stress this financial burden has put on the family has even affected AJ’s mental health.
“He was freaking out about everything,” says Chris, who made sure to provide AJ with a psychotherapist and as relaxing an environment as he can provide given the extreme circumstances.
Today, AJ is still cancer free. He has completely stopped chemotherapy after having more complications. He and his family are seeking less expensive ways to get high-grade cannabis oils, but they have yet to find a more affordable answer before this health crisis literally puts the family in bankruptcy.
AJ’s very brave cancer survival story truly is a medical miracle and another reason cannabis needs to be legalized and affordable for everyone who needs it.
www.gofundme.com/ajkephart

http://ireadculture.com/boy-on-his-deathbed-is-cured-with-cannabis/

normally we do not post testimonials, but this one was especially touching

Tuesday, August 23, 2016

New July 2016 Granny's Storm Crow List

To: stormcrow 

I've put the List on the cloud! Click the link to download the new
2016 Granny Storm Crow's List!

https://1drv.ms/b/s!AkiTiWAuHrKLbx7-n63PHKx_T9I

Just opening the link will show you the List, but you will need to
download it to access the very useful Navigation Index. Click the
"Bookmark" icon if it doesn't automatically show up. No more scrolling
"forever" to get to that study you want!  It may take a minute or so
to download- it's over 3,300 pages!

The first section of the List is over 475 pages of links to news
articles, so you won't need a PhD to use the List. Reading a news
article about something first, really makes understanding the actual
medical study much easier!

The second section is devoted to the more recent medical studies and
articles from 2010 to the beginning of August 2016. For people
seriously looking into cannabis and the cannabinoids, this will likely
be the most useful section for a lot of you.

Further down are the older studies that go into detail about some of
the basic questions (how long to hold a hit, storage of cannabis,
effects on hormone levels, etc). The older studies also tend to be
easier to understand, so they are a good place to begin your
education.

At the very bottom is a small mini-dictionary of words you will run
across in the studies. You might even want to print up a copy of it just
as a handy reference until you get used to all of the "Sci-speak"!

And take your Omega 3! It is needed to properly make the CB receptors
that the cannabinoids (like THC and CBD) activate to get you "high",
and also, more importantly, heal you. You want lots of working CB
receptors, and not just for the better "high" that daily use of Omega
3 can bring after a month or two!

And one last thank you to "Old Hippie" (of the "Beyond Chronic" blog)
for his invaluable technical help in getting this List out to all of
you! "Nugs and Hugs" to you, my friend!

I hope you enjoy my List,

Granny

Monday, August 1, 2016

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.

http://www.ncbi.nlm.nih.gov/pubmed/26517407
Eur J Pain. 2016 Jul;20(6):936-48. doi: 10.1002/ejp.818. Epub 2015 Oct 30.

Abstract

BACKGROUND:

Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. Cannabidiol (CBD) attenuates inflammation and pain without side-effects, but CBD is hydrophobic and has poor oral bioavailability. Topical drug application avoids gastrointestinal administration, first pass metabolism, providing more constant plasma levels.

METHODS:

This study examined efficacy of transdermal CBD for reduction in inflammation and pain, assessing any adverse effects in a rat complete Freund's adjuvant-induced monoarthritic knee joint model. CBD gels (0.6, 3.1, 6.2 or 62.3 mg/day) were applied for 4 consecutive days after arthritis induction. Joint circumference and immune cell invasion in histological sections were measured to indicate level of inflammation. Paw withdrawal latency (PWL) in response to noxious heat stimulation determined nociceptive sensitization, and exploratory behaviour ascertained animal's activity level.

RESULTS:

Measurement of plasma CBD concentration provided by transdermal absorption revealed linearity with 0.6-6.2 mg/day doses. Transdermal CBD gel significantly reduced joint swelling, limb posture scores as a rating of spontaneous pain, immune cell infiltration and thickening of the synovial membrane in a dose-dependent manner. PWL recovered to near baseline level. Immunohistochemical analysis of spinal cord (CGRP, OX42) and dorsal root ganglia (TNFα) revealed dose-dependent reductions of pro-inflammatory biomarkers. Results showed 6.2 and 62 mg/day were effective doses. Exploratory behaviour was not altered by CBD indicating limited effect on higher brain function.

CONCLUSIONS:

These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.
© 2015 European Pain Federation - EFIC®
PMID:
26517407
PMCID:
PMC4851925
DOI:
10.1002/ejp.818
[PubMed - in process]
Free PMC Article

Monday, July 25, 2016

Anticancer mechanisms of cannabinoids.

http://www.ncbi.nlm.nih.gov/pubmed/27022311

Curr Oncol. 2016 Mar;23(2):S23-32. doi: 10.3747/co.23.3080. Epub 2016 Mar 16.

Abstract

In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body of evidence shows that these molecules can decrease tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival. In addition, cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals. In this review, we discuss the current understanding of cannabinoids as antitumour agents, focusing on recent discoveries about their molecular mechanisms of action, including resistance mechanisms and opportunities for their use in combination therapy. Those observations have already contributed to the foundation for the development of the first clinical studies that will analyze the safety and potential clinical benefit of cannabinoids as anticancer agents.

KEYWORDS:

Cannabinoids; angiogenesis; apoptosis; autophagy; cell proliferation; cell signalling; combination therapy

Wednesday, June 29, 2016

Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells

http://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/


Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons
LA JOLLA–Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.
While these exploratory studies were conducted in neurons grown in the laboratory, they may offer insight into the role of inflammation in Alzheimer’s disease and could provide clues to developing novel therapeutics for the disorder.
“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” says Salk Professor David Schubert, the senior author of the paper.
Alzheimer’s disease is a progressive brain disorder that leads to memory loss and can seriously impair a person’s ability to carry out daily tasks. It affects more than five million Americans according to the National Institutes of Health, and is a leading cause of death. It is also the most common cause of dementia and its incidence is expected to triple during the next 50 years.
It has long been known that amyloid beta accumulates within the nerve cells of the aging brain well before the appearance of Alzheimer’s disease symptoms and plaques. Amyloid beta is a major component of the plaque deposits that are a hallmark of the disease. But the precise role of amyloid beta and the plaques it forms in the disease process remains unclear.
David-Schubert
David Schubert, Professor of Salk’s Cellular Neurobiology Laboratory Click here for a high resolution image
Credit: Salk Institute
In a manuscript published in June 2016’s Aging and Mechanisms of Disease, the Salk team studied nerve cells altered to produce high levels of amyloid beta to mimic aspects of Alzheimer’s disease.
The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.
“Inflammation within the brain is a major component of the damage associated with Alzheimer’s disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves,” says Antonio Currais, a postdoctoral researcher in Schubert’s laboratory and first author of the paper. “When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying.”
Brain cells have switches known as receptors that can be activated by endocannabinoids, a class of lipid molecules made by the body that are used for intercellular signaling in the brain. The psychoactive effects of marijuana are caused by THC, a molecule similar in activity to endocannabinoids that can activate the same receptors. Physical activity results in the production of endocannabinoids and some studies have shown that exercise may slow the progression of Alzheimer’s disease.
Schubert emphasized that his team’s findings were conducted in exploratory laboratory models, and that the use of THC-like compounds as a therapy would need to be tested in clinical trials.
In separate but related research, his lab found an Alzheimer’s drug candidate called J147 that also removes amyloid beta from nerve cells and reduces the inflammatory response in both nerve cells and the brain. It was the study of J147 that led the scientists to discover that endocannabinoids are involved in the removal of amyloid beta and the reduction of inflammation.
Other authors on the paper include Oswald Quehenberger and Aaron Armando at the University of California, San Diego; and Pamela Maher and Daniel Daughtery at the Salk Institute.
The study was supported by the National Institutes of Health, The Burns Foundation and The Bundy Foundation.
PUBLICATION INFORMATION

JOURNAL
Aging and Mechanisms of Disease
AUTHORS
Antonio Currais, Oswald Quehenberger, Aaron M Armando, Daniel Daugherty, Pam Maher & David Schubert