Sunday, September 19, 2010

Understanding How THC Kills Cancer in Humans by Dennis Hill

Understanding How THC Kills Cancer in Humans

First let’s look at what keeps cancer cells alive, then we will come back and examine
how THC unravels cancer’s aliveness.
In every cell there is a family of interconvertible sphingolipids that specically manage the life and death of that cell. is pro le of factors is called the “Sphingolipid Rheostat.” If ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its aliveness.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the
cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous
mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein
called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. is means
taking therapeutic amounts of THC, steadily, over a period of time, keeping metabolic
pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant
enzyme and use it for profound healing in many di erent physiological systems? is
endocannabinoid system exists in all animals of creation, just waiting for it’s matched exocannabinoid activator.
This is amazing. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information owing between our immune system and the central nervous
system (CNS). It is responsible for neuroprotection, and micro-manages the immune
system. is is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls desperately to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids are therapeutic. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule,
where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 gives us the buzz, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is better for buzz, and indica is better for healing. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is said that THC and CBD are biomimetic to anandamide, that is, the body can use
both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids can rush to the rescue. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to
the body’s immune system. From there, immune cells seek out and destroy cancer cells.
Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. is means that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to
leave you in complete amazement that nature has designed the perfect medicine that ts
exactly with our own immune system of receptors and signaling metabolites to provide
perfect health all the time. It is my hope that my own prostate cancer dies out quickly in the face of intensive cannabis extract treatment currently in progress. The C-T Scan will tell the story next month.

~Dennis Hill
Legal in California


Bibliography

1. http://cancerres.aacrjournals.org/content/65/5/1635.abstract
Sami Sarfaraz, Farrukh Afaq, Vaqar M. Adhami, and Hasan Mukhtar + Author
Affiliations. Department of Dermatology, University of Wisconsin, Madison,
Wisconsin

2. http://www.ncbi.nlm.nih.gov/sites/pubmed
J Neuroimmunol. 2007 Mar;184(1-2):127-35. Epub 2006 Dec 28.
Immune control by endocannabinoids - new mechanisms of neuroprotection?
Ullrich O, Merker K, Timm J, Tauber S.
Institute of Immunology, Medical Faculty, Otto-von-Guericke-University
Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
oliver.ullrich@medizine.uni-magdeburg.de

3. http://en.wikipedia.org/wiki/Endocannabinoid_system
Endocannabinoid synthesis & release.

4. http://en.wikipedia.org/wiki/Cannabinoids
Cannabinoid receptor type 1.

5. http://www3.interscience.wiley.com/journal/121381780/abstract?
CRETRY=1&SRETRY=0

Journal of Neurochemistry, Volume 104 Issue 4, Pages 1091 - 1100
Published Online: 18 Aug 2008

6. http://leavesofgrass.info/info/Non-Psychoactive-Cannabinoids.pdf
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an
ancient herb.
Angelo A. Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, and
Raphael Mechoulam. Department of Experimental Pharmacology, University
of Naples Federico II, Naples, Italy. Institute of Biomolecular Chemistry,
National Research Council, Pozzuoli (NA), Italy. Department of Medicinal
Chemistry and Natural Products, Hebrew University Medical Faculty,
Jerusalem, Israel, Endocannabinoid Research Group, Italy

7. http://sciencenews.org/view/feature/id/59872/title/Not_just_a_high
Scientists test medicinal marijuana against MS, inflammation and cancer
By Nathan Seppa June 19th, 2010; Vol.177 #13 (p. 16)

8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766198/?tool=pmcentrez
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in
programmed cell death.

Tarek A. Taha, Thomas D. Mullen, and Lina M. Obeid
Division of General Internal Medicine, Ralph H. Johnson Veterans
Administration Hospital, Charleston, South Carolina 29401; and Department
of Medicine, Medical University of South Carolina, Charleston, South Carolina
29425

Thursday, August 12, 2010

Q&A about making Rick Simpson Hemp Oil

recently someone was asking me questions about the process of making Rick Simpson Hemp Oil, so I thought I would answer here, but leave the asker anonymous. My answers will be in red.

See my post here below for the full reading on how to make Rick Simpson Hemp Oil
http://ricksimpsonhempoil.blogspot.com/2010/08/how-to-make-hemp-oil-by-rick-simpson.html

The message they sent you was:

Hi i saw your blog before and aware of the pic, it is very nice. I am also looking at the other link u sent and is reading it now, i have several thing i dont understand:

11- Boil the solvent off. I have found that a rice cooker will do this boil off very nicely. The one I have has two heat settings - high and low - and will hold over a half gallon (2.5 liters) of solvent-oil mix.

question: this boil the solvent off, meaning the solvent and oil mix right?

Yes

12- Add solvent-oil mix to the rice cooker until it is about ¾ full.

question: is it 3/4 of full are the content from the mix of 1 pound? there are more to it usually? if so how much more?

No, the full content will use about 2 gallons of solvent (8 liters), so it will not fit into the rice cooker all at once. You must add a partial amount in, then wait for it to boil down to a lower level so you can add more solvent mix in ... repeat this until finally you can put all the solvent in.

14- Continue adding solvent-oil mix as the level in the rice cooker decreases until it is all in the cooker.

question: the extra solvent oil mix is from the same batch but doesnt fit in the rice cooker at the beginning right? the lvl of rice cooker decreases meaning the exisiting solvent oil mix in the rice cooker right?

15- Add a few drops of water to the solvent-oil mix as the level comes down for the last time. The amount of water added depends on how much starting material you had in the beginning. If I am producing oil from a pound of good bud, I usually add about ten drops of water.

question: add water as the lvl comes down for the last time =======> i dont understand this at all what does this means?

once you have added all the solvent in (all 2 gallons/8 liters), then it will boil down for the last time. Once it reaches about 2 inches, it is almost done, it is at this point where you can add a few drops of water in. I personally don't see why this is necessary, but hey I'm not the famous one so I'll keep my mouth shut on this. :)

16- When there is about one inch of solvent-oil-water mix left in the cooker, put on your oven mitts, pick the unit up and gently swirl the contents.

QUESTION: basically pick up the rice cooker and turn it slowly to mix the oil?

yes, swirl it in a circle to help keep the mix moving so the heat is evenly distributed and it doesn't burn.

17- Continue swirling until the solvent has been evaporated off. The few drops of water help release the solvent residue and protect the oil somewhat from too much heat. When the solvent has been boiled off, the cooker that I use automatically goes to low heat. This avoids any danger of overheating the oil. At no time should the temperature of the oil go over 290F degrees (140 C).

question: how do i tell when the solvent is evaporated off?

The solvent will boil like boiling water as it is boiling off. Once there is no more solvent left, the boiling will stop, and you will be left with a blackish gooey substance (hemp oil). The rice cooker will automatically turn to lower heat once this happens, since once it reaches over 212 degrees F, it means all the water is boiled off and thus the solvent is also boiled off, since the solvent boils at a lower temperature than water. So, the rick cooker will automatically turn to lower heat setting for you really.



____________________________________________________________________

On Sun, Aug 29, 2010 at 8:51 PM xxxxxxx@gmail.com> wrote:

I've read some of your posts from Phoenix Tears and you sound like a person who knows what they are doing. My question is "can water be used as a solvent during the process of making the oil?"

I am very uneasy about using naphtha or isopropyl alcohol, as these are both toxic to begin with, and am curious as to what you think.

Thank you for reading.



hi

Thanks for writing. Unfortunately, no, water cannot be used as a solvent for making hemp oil. The active ingredients do not dissolve in water. You have to use a solvent, however the boiling point of the solvents are fairly low (below water boiling). So, if you boil long enough, theoretically all the solvent should be evaporated by the time you take it. If you are still worried, you can put the final batch under a warm area with a fan for several days. The alcohol/solvents will evaporate off very completely given enough time if you left some.

let me know if you have any more questions! thanks

How to make hemp oil by Rick Simpson

Cannabis North Ireland great guide to making Hemp Oil

I saw this great guide for making Hemp Oil from Cannabisni.com, and wanted to share it here as it is a great information resource

http://www.cannabisni.com/medicinal-cannabis-news/1194-how-to-make-hemp-oil-by-rick-simpson

How to make hemp oil by Rick Simpson

For those of you who have watched the documentary "Run from the Cure", this should answer any questions about producing your own hemp oil.

hemp oil cures cancer



Caution:
Oils that drug dealers sell can have many contaminants and often little or no THC. From my experience, most hemp oil available on the street should be avoided for medicinal use. Make your own oil or have someone you trust produce the oil to assure a very pure, high quality oil is produced.

How much to make and take?
One pound (500g) of bone-dry hemp buds will usually produce about 2 ounces (55 - 60 mL) of high-grade oil. This amount of oil will cure most serious cancers; the average person can ingest this amount in about three months. This oil is very potent so one must begin treatment with small doses. A drop of oil about half the size of a grain of rice, two to four times a day is a good beginning. After four or five days, start increasing your daily dosage very gradually. As time goes on the body builds a tolerance to the oil and more and more can be taken. In cases where people are in a great deal of pain, I recommend that their dosage be quickly increased until it kills the pain. High quality hemp oil will stop pain even when morphine is not effective. The oil can be applied to external injuries for pain relief in minutes.

Will I get high?
Following the dosage previously described, many people can take the full treatment and never get high. In regards to hemp, getting "high" is a joke, even if a person does take too much oil the effect wears off quickly and no harm is done. No one has ever died from the use of hemp medicine.

Will I become addicted?
Hemp oil does not cause your body to crave more. It is non-addictive, harmless and effective for practically any medical condition.

Is this the same as hemp seed oil?
No! This is hemp oil, made from the bud and small leaves of the hemp plant. It is the essential oil of the hemp plant. Health food store sells oil made from hemp seed that is often mislabeled as hemp oil. Although seed oil is very beneficial, it does not contain enough THC to have any effect on cancer and other serious illnesses.

Are hemp and marijuana the same?
The word marijuana is one of over four hundred slang terms used worldwide to describe the cannabis and/or hemp plant.

Are all hemp plants the same?
When buying or growing hemp, procure a strain that has the highest possible THC content. To energize someone suffering from depression, I recommend a good Sativa strain. For most other medical conditions, I strongly suggest that Indica strains be used. Indicas relax a person and provide them with more rest and sleep.

How do I use it?
High quality hemp oil can be vapourized, ingested or used topically. Add the oil to creams and salves for external use.

Where can I get information about making the oil?

The process in the video could only be described as crude at best, but the oil that is produced will cure cancer. In reality, this medicine should be produced in a controlled environment, using distilling equipment, etc. to reclaim the solvent and to purify the oil. Most people do not understand distilling and do not have access to the required equipment. This is the reason such a simple method is descried in the documentary, so if need be just about anyone can produce the oil. As in the video, again we stress that this process, if not done properly can be dangerous and we bear no responsibility if this educational information is misused.

Rick Simpsons process of making hemp oil

Starting material:
I generally work with a pound or more of good grade hemp starting material. You can use just one ounce. An ounce will usually produce 3 or 4 grams of oil. The amount of oil produced per ounce of hemp will vary from strain to strain, but it all has that wonderful healing power.

1 - Place the completely dry starting material in a plastic bucket.



2 - Dampen the material with the solvent you are using. Many solvents can be used. I like to use pure naphtha but it costs $500 for a 45-gallon drum. You can use 99% isopropyl alcohol, which you can find in your local drug stores. Alcohol absorbs more chlorophyll from the plant material than naphtha does. This gives oils made with alcohol a darker colour but does not diminish the potency of the oil to any noticeable degree. Ether, naphtha or butane and many other solvents can produce oils that are amber and transparent. Granted these clear oils do look better but dark oil can be just as potent. If the process is done properly, little or no solvent residue is left in the oil. I have been consuming oils produced using different solvents for eight years with no harmful effects. You will require about two gallons of solvent to strip the THC off one pound of dry starting material. 500 milliliters of solvent should be more than enough to strip the THC from one ounce of hemp starting material.


3 - Crush the plant material using a stick of clean untreated (chemical free) wood or some such device. Even though the starting material has been dampened with the solvent, you will find that the material can be readily crushed.


4 - Add solvent until the starting material is completely covered.
Use the stick to work the plant material. As you are doing this, the THC dissolves off the plant material into the solvent.


5 - Continue this process for about 3 minutes.


6 - Pour the solvent-oil mix off the plant material into another bucket. You have just stripped the plant material of about 80% of its THC.


7 - Second wash - again add solvent to the plant material and work it for another 3 minutes to get the other 20%.


8 - Pour this solvent-oil mix into the bucket containing the first mix that was poured off previously.


9 - Discard the twice-washed plant material.


10- Pour the solvent-oil mix through a coffee filter into a clean container.


11- Boil the solvent off. I have found that a rice cooker will do this boil off very nicely. The one I have has two heat settings - high and low - and will hold over a half gallon (2.5 liters) of solvent-oil mix.


12- Add solvent-oil mix to the rice cooker until it is about ¾ full.

Make sure you are in a very well ventilated area and set up a fan to carry the solvent fumes away. The fumes are very flammable. Be sure to stay away from red-hot elements, sparks, cigarettes etc. that could ignite the fumes.


13- Plug the rice cooker in and set it on high heat.


14- Continue adding solvent-oil mix as the level in the rice cooker decreases until it is all in the cooker.


15- Add a few drops of water to the solvent-oil mix as the level comes down for the last time. The amount of water added depends on how much starting material you had in the beginning. If I am producing oil from a pound of good bud, I usually add about ten drops of water.


16- When there is about one inch of solvent-oil-water mix left in the cooker, put on your oven mitts, pick the unit up and gently swirl the contents.


17- Continue swirling until the solvent has been evaporated off. The few drops of water help release the solvent residue and protect the oil somewhat from too much heat. When the solvent has been boiled off, the cooker that I use automatically goes to low heat. This avoids any danger of overheating the oil. At no time should the temperature of the oil go over 290F degrees (140 C).


18- Put on your oven mitts and remove the pot containing the oil from the rice cooker.


19- Gently pour the oil into a small stainless steel container.


20- Place this container in a dehydrator or put in on a gentle heating device such as a coffee warmer. It may take a few hours but the water and volatile turpines will be evaporated from the oil. When there is no longer any activity on the surface of the oil the medicine is ready for use.


21- Pour the hot oil into a bottle; or as in the video suck it up into a plastic syringe. Putting the oil in a plastic syringe makes it very easy to dispense the medicine.


When the oil cools off it has the consistency of thick grease. Some strains will produce very thick oil and you may have trouble squeezing it out of the syringe. If this happens, place the syringe in warm water a few minutes prior to use.

To anyone starting to use hemp oil as a medication, here are some simple facts.

Hemp oil will lower blood pressure and if you are on blood pressure medication, you may find that this medication is no longer needed. The same is true for diabetics. I have seen hemp oil control blood sugar to the extent that insulin was no longer needed.

I am not a doctor and I do not have the right to tell people what they should do. Personally, I would not consider taking any cancer treatments currently in use by our medical system, I do not recommend that hemp oil be taken along with chemotherapy. What would be the sense of making your own cure and then allowing the medical system to give you massive doses of poison?

From my experience with hemp medicine, I have found that most pharmaceutical medications are no longer needed once a person starts using hemp oil. Hemp oil seems to mix well with most natural medications but I have had a few reports from people trying to take hemp oil and pharmaceuticals who experienced stomach pain etc. All problems ceased when they stopped taking the prescription drugs.

To anyone who is going to act on this information to help a loved one, I welcome you to the world of real medicine. Again, I caution you to be very careful when boiling the solvent off. The fumes are very flammable. Be sure to stay away from red-hot elements, sparks, cigarettes etc. that could ignite the fumes.

I wish you the best luck and health.
Warmest regards,
Rick Simpson.

Source www.phoenixtears.ca

Wednesday, July 28, 2010

Live making of Hemp Oil

recent oil run starting from 1 pound of flowers

starting material
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bucket with filter attached
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material in bucket
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material in bucket with solvent
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material getting strained
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purified strained oil
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cooking in the rice cooker
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boiling down
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now its all gooey, lets suck it up
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in syringes and ready to go. yielded about 2 oz of oil
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Tuesday, July 27, 2010

First Post - Rick Simpson Hemp Oil available

californiatears@gmail.com

Will be posting pictures and updates later, this is the current contact info for questions, information on how to make, locating the oil, healing and much more info!