Tuesday, August 23, 2016

New July 2016 Granny's Storm Crow List

To: stormcrow 

I've put the List on the cloud! Click the link to download the new
2016 Granny Storm Crow's List!

https://1drv.ms/b/s!AkiTiWAuHrKLbx7-n63PHKx_T9I

Just opening the link will show you the List, but you will need to
download it to access the very useful Navigation Index. Click the
"Bookmark" icon if it doesn't automatically show up. No more scrolling
"forever" to get to that study you want!  It may take a minute or so
to download- it's over 3,300 pages!

The first section of the List is over 475 pages of links to news
articles, so you won't need a PhD to use the List. Reading a news
article about something first, really makes understanding the actual
medical study much easier!

The second section is devoted to the more recent medical studies and
articles from 2010 to the beginning of August 2016. For people
seriously looking into cannabis and the cannabinoids, this will likely
be the most useful section for a lot of you.

Further down are the older studies that go into detail about some of
the basic questions (how long to hold a hit, storage of cannabis,
effects on hormone levels, etc). The older studies also tend to be
easier to understand, so they are a good place to begin your
education.

At the very bottom is a small mini-dictionary of words you will run
across in the studies. You might even want to print up a copy of it just
as a handy reference until you get used to all of the "Sci-speak"!

And take your Omega 3! It is needed to properly make the CB receptors
that the cannabinoids (like THC and CBD) activate to get you "high",
and also, more importantly, heal you. You want lots of working CB
receptors, and not just for the better "high" that daily use of Omega
3 can bring after a month or two!

And one last thank you to "Old Hippie" (of the "Beyond Chronic" blog)
for his invaluable technical help in getting this List out to all of
you! "Nugs and Hugs" to you, my friend!

I hope you enjoy my List,

Granny

Monday, August 1, 2016

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.

http://www.ncbi.nlm.nih.gov/pubmed/26517407
Eur J Pain. 2016 Jul;20(6):936-48. doi: 10.1002/ejp.818. Epub 2015 Oct 30.

Abstract

BACKGROUND:

Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. Cannabidiol (CBD) attenuates inflammation and pain without side-effects, but CBD is hydrophobic and has poor oral bioavailability. Topical drug application avoids gastrointestinal administration, first pass metabolism, providing more constant plasma levels.

METHODS:

This study examined efficacy of transdermal CBD for reduction in inflammation and pain, assessing any adverse effects in a rat complete Freund's adjuvant-induced monoarthritic knee joint model. CBD gels (0.6, 3.1, 6.2 or 62.3 mg/day) were applied for 4 consecutive days after arthritis induction. Joint circumference and immune cell invasion in histological sections were measured to indicate level of inflammation. Paw withdrawal latency (PWL) in response to noxious heat stimulation determined nociceptive sensitization, and exploratory behaviour ascertained animal's activity level.

RESULTS:

Measurement of plasma CBD concentration provided by transdermal absorption revealed linearity with 0.6-6.2 mg/day doses. Transdermal CBD gel significantly reduced joint swelling, limb posture scores as a rating of spontaneous pain, immune cell infiltration and thickening of the synovial membrane in a dose-dependent manner. PWL recovered to near baseline level. Immunohistochemical analysis of spinal cord (CGRP, OX42) and dorsal root ganglia (TNF╬▒) revealed dose-dependent reductions of pro-inflammatory biomarkers. Results showed 6.2 and 62 mg/day were effective doses. Exploratory behaviour was not altered by CBD indicating limited effect on higher brain function.

CONCLUSIONS:

These data indicate that topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.
© 2015 European Pain Federation - EFIC®
PMID:
26517407
PMCID:
PMC4851925
DOI:
10.1002/ejp.818
[PubMed - in process]
Free PMC Article