Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro and in vivo.

https://www.ncbi.nlm.nih.gov/pubmed/27778331

Int J Cancer. 2017 Feb 1;140(3):674-685. doi: 10.1002/ijc.30483. Epub 2016 Nov 10.

Barbado MV¹, Medrano M¹, Caballero-Velázquez T¹, Álvarez-Laderas I¹, Sánchez-Abarca LI¹, García-Guerrero E¹, Martín-Sánchez J¹, Rosado IV¹, Piruat JI¹, Gonzalez-Naranjo P², Campillo NE², Páez JA², Pérez-Simón JA¹.

Author information

Abstract

Although hematopoietic and immune system show high levels of the cannabinoid receptor CB2, the potential effect of cannabinoids on hematologic malignancies has been poorly determined. Here we have investigated their anti-tumor effect in multiple myeloma (MM). We demonstrate that cannabinoids induce a selective apoptosis in MM cell lines and in primary plasma cells of MM patients, while sparing normal cells from healthy donors, including hematopoietic stem cells. This effect was mediated by caspase activation, mainly caspase-2, and was partially prevented by a pan-caspase inhibitor. Their pro-apoptotic effect was correlated with an increased expression of Bax and Bak, a decrease of Bcl-xL and Mcl-1, a biphasic response of Akt/PKB and an increase in the levels of ceramide in MM cells. Inhibition of ceramide synthesis partially prevented apoptosis, indicating that these sphingolipids play a key role in the pro-apoptotic effect of cannabinoids in MM cells. Remarkably, blockage of the CB2 receptor also inhibited cannabinoid-induced apoptosis. Cannabinoid derivative WIN-55 enhanced the anti-myeloma activity of dexamethasone and melphalan overcoming resistance to melphalan in vitro. Finally, administration of cannabinoid WIN-55 to plasmacytoma-bearing mice significantly suppressed tumor growth in vivo. Together, our data suggest that cannabinoids may be considered as potential therapeutic agents in the treatment of MM.


© 2016 UICC.

KEYWORDS:

apoptosis; cannabinoids; caspases; ceramides; multiple myeloma

PMID:

27778331

DOI:

10.1002/ijc.30483

[PubMed - in process]

U.S.: Hemp Industry Association Says DEA Ruling Does Not Make CBD Illegal

http://crrh.org/news/blog/1582

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
- See more at: http://crrh.org/news/blog/1582#sthash.8DMXosgI.dpuf

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
HIA strongly disagrees with the DEA position and is ready to take action to defend should DEA take any action to block the production, processing or sale of hemp under Sec. 7606.
The Final Rule published on December 14th was not a scheduling action but rather an administrative action related to record keeping.

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
- See more at: http://crrh.org/news/blog/1582#sthash.8DMXosgI.dpuf

 

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
HIA strongly disagrees with the DEA position and is ready to take action to defend should DEA take any action to block the production, processing or sale of hemp under Sec. 7606.
The Final Rule published on December 14th was not a scheduling action but rather an administrative action related to record keeping.
- See more at: http://crrh.org/news/DEA-did-not-make-CBD-illegal-after-all-despite-reports-to-the-contrary#sthash.hLXbgO4d.dpuf

 

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
HIA strongly disagrees with the DEA position and is ready to take action to defend should DEA take any action to block the production, processing or sale of hemp under Sec. 7606.
The Final Rule published on December 14th was not a scheduling action but rather an administrative action related to record keeping.
- See more at: http://crrh.org/news/DEA-did-not-make-CBD-illegal-after-all-despite-reports-to-the-contrary#sthash.hLXbgO4d.dpuf

 

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
HIA strongly disagrees with the DEA position and is ready to take action to defend should DEA take any action to block the production, processing or sale of hemp under Sec. 7606.
The Final Rule published on December 14th was not a scheduling action but rather an administrative action related to record keeping.
- See more at: http://crrh.org/news/DEA-did-not-make-CBD-illegal-after-all-despite-reports-to-the-contrary#sthash.hLXbgO4d.dpuf

Fri, 12/16/2016 - 04:11 - derrickstanley

• 2016 |
• Marijuana |
• Hemp Industry Association |
• Industrial Hemp |
• cannabidiol |
• CBD

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
HIA strongly disagrees with the DEA position and is ready to take action to defend should DEA take any action to block the production, processing or sale of hemp under Sec. 7606.
The Final Rule published on December 14th was not a scheduling action but rather an administrative action related to record keeping.

- See more at: http://crrh.org/news/DEA-did-not-make-CBD-illegal-after-all-despite-reports-to-the-contrary#sthash.hLXbgO4d.dpuf

Fri, 12/16/2016 - 04:11 - derrickstanley

• 2016 |
• Marijuana |
• Hemp Industry Association |
• Industrial Hemp |
• cannabidiol |
• CBD

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
HIA strongly disagrees with the DEA position and is ready to take action to defend should DEA take any action to block the production, processing or sale of hemp under Sec. 7606.
The Final Rule published on December 14th was not a scheduling action but rather an administrative action related to record keeping.

- See more at: http://crrh.org/news/DEA-did-not-make-CBD-illegal-after-all-despite-reports-to-the-contrary#sthash.hLXbgO4d.dpuf

Fri, 12/16/2016 - 04:11 - derrickstanley

• 2016 |
• Marijuana |
• Hemp Industry Association |
• Industrial Hemp |
• cannabidiol |
• CBD

By Derrick Stanley
Hemp News
The National Hemp Association has made an announcement that a recent ruling by the U.S. DEA (Drug Enforcement Administration) did not make cannabidoids (CBD) illegal.
The following statement was issued by the Hemp Industries Association:
Yesterday the Drug Enforcement Administration (DEA) issued a Final Rule on the coding of marijuana extracts. Unfortunately some misleading media stories and social media postings lead quite a few people to panic at reports that CBD was being banned under this new rule.
The Sky is NOT Falling. The Final Rule published by DEA did not change the legal status of CBD. This can only be done by a scheduling action which has NOT occurred.
HIA has carefully reviewed this with our legal advisors and discussed it with industry experts. While there are some differing opinions on the effect of the rule, there is general agreement that yesterday's ruling did not change the status of CBD. Here are some important facts to know:
Cannabidiol is not listed on the federal schedule of controlled substances
Sec. 7606 of the Farm Bill defines hemp as distinct from marijuana and does not treat it as a controlled substance when grown under a compliant state program.
Despite these facts, DEA has stated that CBD is a controlled substance previously.
HIA strongly disagrees with the DEA position and is ready to take action to defend should DEA take any action to block the production, processing or sale of hemp under Sec. 7606.
The Final Rule published on December 14th was not a scheduling action but rather an administrative action related to record keeping.

- See more at: http://crrh.org/news/DEA-did-not-make-CBD-illegal-after-all-despite-reports-to-the-contrary#sthash.hLXbgO4d.dpuf